| Company Name | Product / Services | Employee Size |
| Lafayette General Medical Ctr | Health Care | 6724 |
| Opelousas Health Systems | Health Care | 2000 |
| Stuller Inc | Jewelry-Manufacturers | 1600 |
| Our Lady Of Lourdes Regl Med | Health Care | 1493 |
| Baker Hughes | Oil Field Service | 1339 |
| Superior Energy Svc | Oil Field Service | 1320 |
| Schlumberger | Oil Field Service | 1314 |
| Frank's Casing Crew & Rental | Oil Field Service | 1222 |
| Halliburton Energy SVC | Oil Field Service | 1152 |
| Regional Medical Ctr-Acadiana | Health Care | 1135 |
| Walmart Distribution Ctr | Distribution Centers (Whls) | 952 |
| Quality Construction & Prdctn | General Contractors | 950 |
| Weatherford | Oil Field Service | 839 |
| Acadian Companies | Health Care | 799 |
| AT&T WIRELESS | Telecommunications | 710 |
| LHC Group Inc | Health Care | 700 |
| McDonald's of Acadiana | Service | 689 |
| Cheveron USA Production Co. | Oil and Gas | 650 |
| Walmart Stores Inc. | Retail | 617 |
| Petroleum Helicopters Inc. | Transportation | 600 |
| Offshore Energy Inc | Oil Field Service | 530 |
| Cameron Valves & Measurement | Valves-Manufacturers | 525 |
| Cal Dive Intl Inc | Diving Instruction | 520 |
| Fieldwood Energy | Oil and Gas | 520 |
| American Legion Hospital | Health Care | 511 |
| Dynamic Industries Inc | Oil Field Service | 500 |
| Iberia Medical Ctr | Health Care | 500 |
| Key Energy Svc | Oil Field Service | 500 |
| Omega Natchiq Inc | Oil Field Service | 500 |
| United Vision Logistics | Trucking-Heavy Hauling | 500 |
| Albemarle Corp | Chemicals-Manufacturers | 475 |
| Fugro Geo Svc | Geological Consultants | 450 |
| Gulf Coast Teaching Family Svc | Marriage & Family Counselors | 450 |
| Greene's Energy Group | Energy Management Systems & Products | 401 |
| Bruce Foods Corp | Food Products & Manufacturers | 400 |
| Dauterive Hospital | Health Care | 400 |
| Halliburton Sperry Drilling | Drilling & Boring Contractors | 400 |
| Public Works Dept-Lafayette | Parking Area/Lots Maintenance & Marking | 400 |
| Savoy Medical Ctr | Health Care | 400 |
| St Martin | Health Care | 400 |
| Viscardi Industrial Svc LLC | Building Contractors | 400 |
| Bristow US LLC | Transportation | 400 |
| Alleman Center | Social Service & Welfare Organizations | 350 |
| Ernest P Breaux Elecl Inc | Electric Contractors | 350 |
| Fugro Chance Inc | Surveyors-Marine | 350 |
| Mercy Regional Medical Ctr | Health Care | 350 |
| Waveland Corp | Sandblasting | 350 |
| Abbeville General Hospital | Health Care | 300 |
| Moncla Marine LLC | Oil Field Service | 300 |
| Omega Protein Inc | Fish By-Products (Mfrs) | 300 |
| Trussco Inc | Oil Field Service | 300 |
| C & C Technologies Survey Svc | Surveyors-Land | 300 |
